Bonnie Langford and Gary Wilmot will take over from Samantha Bond and John Marquez in the West End run of Dirty Rotten Scoundrels from 16 September.
The show's principals Robert Lindsay, Rufus Hound and Katherine Kingsley will continue with their performances as Lawrence Jameson, Freddy Benson and Christine Colgate.
Dirty Rotten Scoundrels is based on the popular 1988 film starring Michael Caine and Steve Martin, directed by Frank Oz.
Set on the French Riviera, the story sees the decadent world of sophisticated conman Lawrence Jameson come crashing down with the arrival of larger-than-life Freddy Benson - a conman of an entirely different order.
The two find themselves going head to head, pulling out all the stops in a bid for the affections of millionaire soap heiress Christine Colgate.
The show features music and lyrics by Drama Desk Award winner David Yazbek (The Full Monty) and book by the Golden Globe and Emmy-Award winning Jeffrey Lane (Mad About You).
It's directed at the Savoy Theatre by multi award-winner Jerry Mitchell.
