Jenna Russell will lead the cast of the West End transfer of Urinetown when it opens at the Apollo Theatre in September.
The musical theatre star will reprise her role of Penelope Pennywise from the St James Theatre run in Jamie Lloyd's production.
Richard Fleeshman will not return to the show, citing 'other commitments' on Twitter, but he wished it every success.
Many of the other cast members from the St James will return, including RSC actor Jonathan Slinger who plays Officer Lockstock and Eastenders' Marc Elliott who plays Mr McQueen.
Full casting is to be announced.
Written by Mark Hollmann and Greg Kotis, Urinetown is set in a Gotham-like city of the future, where a hero leads the people in an uprising against private toilets.
Urinetown is designed by Soutra Gilmour, with choreography by Ann Yee, lighting by Adam Silverman, sound by Terry Jardine and Nick Lidster and musical supervision by Alan Williams.
The transfer will make it a hat trick for Lloyd in the West End, with hisTrafalgar Transformed season at the Trafalgar Studios, and musical The Commitments.